Check out Neurophilosophy for a delightful interview with Heather Perry, one of the very small number of people to have drilled into her skull in hopes of finding enlightenment.
“I wrapped my head up in a towel and we got out of there. A couple of days later, we had another go. We abandoned the hand trepan and got an electric drill instead. I injected myself with a local anaesthetic and then slashed a big T-shaped incision in my scalp, right down to the bone. I was sat there in the bathroom feeling quite relaxed and they started with the drill”
And don’t miss the “Illustrated History of Trepanation” from the same site!